David T. Drummond ⎜Jun 11, 2018 ⎜ Industry
By Wayne Forrest, AuntMinnie.com staff writer.
Major changes are taking place in the intricate network that supplies healthcare providers around the world with molybdenum-99 (Mo-99), a key radioisotope for nuclear medicine studies. The question is, can the nuclear medicine community avoid another devastating shutdown like the one that occurred in 2009?
Back then, providers were left scrambling after a perfect storm left sites without supplies of Mo-99, which cannot be stockpiled due to its extremely short half-life. In the years since the 2009 crisis, nuclear reactor operators, nuclear medicine pharmacies and practitioners, radioisotope generator manufacturers, medical societies, and other stakeholders have banded together to ensure that adequate supplies of Mo-99 and its technetium-99m (Tc-99m) byproduct are consistently available.
“This whole occurrence of 2009 really presented a wake-up call to the industry at large, but I think we have embraced it,” said Sally Schwarz, co-director of the cyclotron facility at the Washington University School of Medicine in St. Louis. “This has been an extensive and time-consuming process to move this change forward.”
One of the more significant steps to Mo-99 stability was the creation in 2009 of a joint effort between the Organization for Economic Cooperation and Development (OECD) and the Nuclear Energy Agency (NEA). The goal is to coordinate Mo-99 production and develop ways to ensure that supply meets worldwide demand; the organizations’ members cover the gamut of nuclear medicine enthusiasts and meet every six months in Paris.
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) and the European Association of Nuclear Medicine (EANM) are also on hand to advocate for physicians who use radioisotopes in the treatment of their patients.
One of the tenets of the OECD-NEA collaborative is to develop an outage reserve capacity. That means Mo-99 suppliers must have permanent arrangements in place to acquire additional capacity to cover shortfalls when reactors go offline for scheduled or unplanned maintenance.
“On the recommendations of the NEA and OECD, there is a 35% contingency supply,” said Cathy Cutler, PhD, director of the Medical Isotope Research and Production (MIRP) program at the Brookhaven National Laboratory. “If someone goes down, you can call on this 35%. They are basically asking radiators to produce this additional amount.”
The outage reserve capacity is maintained by Mo-99 suppliers paying for extra ports and time on a nuclear reactor. If a supply issue occurs, they then have a position in line to acquire additional Mo-99 to cover the shortfall.
The demand for Mo-99 is expected to grow modestly over the next four years, peaking at approximately 11,500 Ci per week. Interestingly, the anticipated upswing follows a reduced call for Mo-99 in 2017. Currently, the OECD estimates that worldwide demand for Mo-99 is at 9,000 six-day Ci per week. Mature markets account for approximately 84% of the demand, while emerging markets take the remaining 16%. The growth rate in mature markets is expected to remain stable at 0.5% through 2021.
Whatever demands are to come will be handled by fewer Mo-99 suppliers, however. On March 31, the National Research Universal (NRU) nuclear reactor in Chalk River, Ontario, Canada, went offline for the final time after serving North America for decades. Even before its permanent closure, the NRU reactor manufactured little if any Mo-99 since October 2016. In addition, the Osiris reactor in France shut down at the end of 2015. Their departure leaves four Mo-99 manufacturers who now must cover the loss.
See full article here: auntminnie.com
David T. Drummond ⎜Jan 19, 2018 ⎜ Calendar
2018 June 23 to 26 @ Pennsylvania Convention Center, Headquarter Hotel: Philadelphia Marriott
isoSolutions is pleased to inform you that we will attend the Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI). You can find us at Booth 1001 in the Pennsylvania Convention Center. We hope to see you there and we can arrange a time and place to meet if you wish.
We look forward to seeing you in Philadelphia, Pennsylvania.
David T. Drummond ⎜Jan 19, 2018 ⎜ Calendar
isoSolutions will be present at the Canadian Nuclear Medicine Annual Scientific Meeting in Vancouver, BC from 2018–03–23 to
More info about the event on canm-acmn.ca
David T. Drummond ⎜Oct 24, 2017 ⎜ Company
“Vancouver, BC – The Western Region Society of Nuclear Medicine (WRSNM) will honor Dr. François Bénard from the BC Cancer Agency with the presentation of their Distinguished Scientist Award. … Dr. Bénard is the Vice President, Research at the BC Cancer Agency, a Distinguished Scientist at the BC Cancer Agency Research Centre and Professor in the Department of Radiology at the University of British Columbia. He is also Associate Dean, Research at the University of British Columbia. In addition he holds the BC Leadership Chair in Functional Cancer Imaging. As a clinician scientist, his research interests are in positron emission tomography (PET), nuclear medicine, cancer imaging and targeted radionuclide therapy. (more…)
Hans Peng ⎜Jun 27, 2017 ⎜ Products
isoSolutions announces the launch of its representation of the Hake Medical Hot Cell, Fume Hood and Shielding Accessories in North and Latin America. In partnership with Hake Medical, isoSolutions is able to provide a complete solution for your radiation protection needs.
In 2016, Hake Medical became the first publically listed company in the field of radiation protection and shielding in China. Hake Medical focuses on providing radiation protection and shielding to nuclear medicine (more…)
David T. Drummond ⎜Oct 25, 2016 ⎜ Calendar
isoSolutions will be present at the Canadian Nuclear Medicine Annual Scientific Meeting in Halifax, Nova Scotia from 2016–04–21 to 2016–04–24.
David T. Drummond ⎜Jun 1, 2016 ⎜ Calendar
The annual meeting of the Society of Nuclear Medicine and Medical Imaging (SNNMI) will be held in Vancouver, Canada from 08 June to 12 June 2013. isoSolutions Marketing & Management Inc. will be exhibiting a wide range of nuclear medicine products.
isoSolutions is presenting a package of products and services for diagnostic and therapeutic radiolabeling applications — a complete labeling solution. isoSolutions can provide a complete range of radioisotopes, including a Ga-68 Generator (iThemba), Lu-177, Y-90, Re-188 and I-131. These products are complemented by a state-of-the-art automated labeling module (Trasis All-in-One) and a complete range of labeling peptides. Finally, expert, experienced consulting services are offered for radiochemistry, licensing (preparation of CMC sections, INDs, DMFs) and grant applications.
isoSolutions also offers an extensive catalog of radiochemicals, radiopharmaceuticals, in-vivo cold kits, stable isotopes, labeled compounds, reagents, shipping containers, laboratory equipment and calibration sources from high quality, reliable suppliers. With isoSolutions, customers can obtain a one-stop shopping service as well as technical support.
David T. Drummond, Managing Director of isoSolutions, states, “We are looking forward to welcoming our customers from North America, South America, China and elsewhere to our booth #1336 at the SNNMI exhibition. We are especially proud that this international congress is being held in our hometown of Vancouver.”