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Bone marrow cell homing to sites of acute tibial fracture: 89Zr-oxine cell labeling with positron emission tomographic imaging in a mouse model

Kevin Yang ⎜Feb 13, 2019 ⎜ Industry

Bone fracture healing is dependent upon the rapid migration and engraftment of bone marrow (BM) progenitor and stem cells to the site of injury. Stromal cell-derived factor-1 plays a crucial role in recruiting BM cells expressing its receptor CXCR4. Recently, a CXCR4 antagonist, plerixafor, has been used to mobilize BM cells into the blood in efforts to enhance cell migration to sites of injury presumably improving healing. (more…)

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First validation of myocardial flow reserve assessed by dynamic 99mTc-sestamibi CZT-SPECT camera

Kevin Yang ⎜Mar 20, 2018 ⎜ Industry

99mTc-sestamibi CZT-SPECT is technically feasible and can provide similar result to 15O-water PET for detecting impaired myocardial flow reserve and abnormal fractional flow reserve in patients with coronary artery disease. This study highlights the diagnostic value of using 99mTc -sestamibi for patients with coronary artery disease.

The WATERDAY study: Denis Agostini & Vincent (more…)

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Prospective of 68Ga Radionuclide Contribution to the Development of Imaging Agents for Infection and Inflammation

David T. Drummond ⎜Mar 14, 2018 ⎜ Industry

During the last decade, the utilization of 68Ga for the development of imaging agents has increased considerably with the leading position in the oncology. The imaging of infection and inflammation is lagging despite strong unmet medical needs. This review presents the potential routes for the development of 68Ga-based agents for the imaging and quantification of infection and inflammation in various diseases and connection of the diagnosis to the treatment for the individualized patient management. (more…)

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Automation of the Radiosynthesis of Six Different 18 F-labeled radiotracers on the AllinOne

David T. Drummond ⎜Nov 15, 2016 ⎜ Products

Background
Fast implementation of positron emission tomography (PET) into clinical and preclinical studies highly demands automated synthesis for the preparation of PET radiopharmaceuticals in a safe and reproducible manner. The aim of this study was to develop automated synthesis methods for these six 18F-labeled radiopharmaceuticals produced on a routine basis at the University of Pennsylvania using (more…)

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UPENN 2016 Automation of the Radiosynthesis of Six radiotracers

David T. Drummond ⎜Sep 24, 2016 ⎜ Products

[18F]ISO-1,
[18F]FTT,
[18F]FTP,
[18F]Fallypride,
[18F]Flubatine and
[18F]F-G
ln produced on a routine basis at UPENN with the Trasis AllinOne synthesizer.

By Ramona Delcea, Trasis Download pdf

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